Alirocumab, sold under the brand name Praluent, is a medication used as a second-line treatment for high cholesterol for adults whose cholesterol is not controlled by diet and statin treatment. When a statin cannot be used or does not work well, Praluent can be used alone or together with other cholesterol lowering medicines. To determine whether to initiate a statin, engage a clinician-patient discussion of potential for ASCVD risk reduction, adverse effects, drug-drug interactions, and patient preferences. 1.2 Primary Hyperlipidemia (including heterozygous familial hypercholesterolemia) PRALUENT is indicated as an adjunct to diet, alone or in combination with other Some patients are required to be on a low fat diet. For instance, your doctor may first prescribe a statin. PRALUENT 75 mg/mL or 150 mg/mL solution for subcutaneous injection in a single-dose pre-filled pen or single-dose pre-filled syringe is supplied in a siliconized 1 mL Type-1 clear glass syringe. It is quite safe and has a low risk of side effects. Chances are the first thing they’ll prescribe is a statin. 2. If statin therapy is chosen: PRALUENT is used in combination with maximally tolerated statin. Praluent contains the active drug alirocumab, which is also a PCSK9 inhibitor. Praluent is used in combination with a statin or a statin and other fat-lowering medicines. It is a human monoclonal antibody that belongs to a novel class of anti-cholesterol drugs, known as PCSK9 inhibitors, and it was the first such agent to receive FDA approval. It is approved to be used in addition to diet and the highest dose of a statin (another drug … Get access to ODYSSEY OUTCOMES trial data and read Important Safety Information on website. And, it’s the only drug that, when combined with a statin, further lowers the risk of cardiovascular disease. It comes in tablet form and needs to be taken only once a day. In the EU, Praluent is approved for use in adults: with primary hypercholesterolemia (heterozygous familial and non-familial) or mixed dyslipidemia, as an adjunct to diet: in combination with a statin or statin with other lipid-lowering therapies in patients unable to reach LDL-C goals with the maximum tolerated dose of a statin or, D) Praluent is prescribed by, or in consultation with, a cardiologist; an endocrinologist; or a physician who focuses in the treatment of cardiovascular (CV) risk management and/or lipid disorders; AND E) If able to tolerate statins, the patient continues to receive the maximum tolerated dose of a statin while receiving Praluent therapy. In addition to cholesterol, sometimes Praluent is also given to heart patients. PCSK9 Inhibitors: Praluent and Repatha What is known is that statin drug levels can increase by anywhere from 80 percent to 260 percent if the medication is taken at the same time as grapefruit. Alirocumab (Praluent) ia man-made prescription drug prescribed in addition to exercise, diet, and statin drugs to reduce LDL cholesterol levels adults with heterozygous familial hypercholesterolemia or adults with heart problems related to excess cholesterol in the body. PRALUENT is available at a lower list price, which may help reduce PRALUENT out-of-pocket cost. Roth EM, et al. Reemphasize healthy life style habits and address other risk factors. Praluent is a PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) inhibitor antibody indicated as adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular (1.1) This drug is used in conjunction with statin cholesterol-lowering drugs. Compared with the combination of statin and ezetimibe, replacing ezetimibe with Praluent cost $997 000 per QALY. a. Praluent is prescribed in conjunction with a statin at the maximally tolerated dose; b. Especially since generic statin … Patient and Physician Perspectives on Mode of Administration of the PCSK9 Monoclonal Antibody Alirocumab, an Injectable Medication to Lower LDL-C Levels: Clin Ther 2015. What it is used for.
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